Pronation of the foot; (Definition:  Pronation is a turning outward of the foot at the ankle, so that person tends to walk on the inner border of the foot.)   is the #1 causes linked to I.T.B Syndrome. Pronation causes the tibia to rotate internally and tighten
 the iliotibial, causing it to rub with more force against the edge of the femur. After a while this produces inflammation and pain.

High or low arches; (Definition:  is an excessively or in-excessively raised arch on the bottom of the foot.) The arch runs from the toes to the heel.prevent the arches in the feet from acting as the natural "shock absorbers" they were designed to be. So, the force of each foot strike (up to 3 times the body's weight) is passed on to the knee area. When this makes the soft tissue structures surrounding the knee tighten, causing the Iliotibial Band to rub with more force against the edge of the femur, eventually producing pain. 

Short Leg Syndrome;  (Definition:  When one leg is shorter then the other) causes the foot on the short leg to excessively plantar flex (the foot and toes are pointed down.) in order to reach the ground. This pulls on the muscles and soft tissues in the outer aspect of the femur, causing the iliotibial band to tighten against the femur. When this happens there is excessive rubbing, friction, and pain on the femur.
Bow-legs;  (Definition:  outward curvature of the leg.) also cause tightening of the soft tissues on the outer aspect of the leg and knee, forcing the Iliotibial Band to rub with greater force against the edge of the femur. This will eventually produce inflammation and pain.